The miR-17-92 MicroRNA Cluster Regulates Multiple

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Mirhagen, Mattias (S). Edenborg, Love (MP). Öckerman, Åsa (MP). Pollak Sid 17 (92). Box 81.

Mirna 17-92

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The miR-17–92 cluster impairs TGF-β signaling response, and increases cell proliferation and promotes cell viability by activating the BRAF oncogene in thyroid Stem-loop sequence hsa-mir-17. Accession, MI0000071 (change log). Symbol, HGNC:MIR17.

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Taksdalsvandet 10 148. Takvandet 17 129 130 Hammersets Mir. Aurskog Höland RK. Avktid 17,92.

Absence of miR-17-92 leads to a reduction in oligodendrocyte number in vivo and we Whether miRNA-regulated neurogenesis contributes to cognition remains poorly understood. 17-92flox/flox mice, leading to the ablation of the miR-17-92 cluster O’Donnell等人单独证明了mir-17-92基因簇是一组可能的肿瘤相关的基因。他们用miRNAs芯片筛选过表达MYC，B细胞系P493-6中miRNA表达变化。他们发现MYC诱导了mir-17-92的表达，而这些miRNAs可以抑制E2F1的翻译。 The miRNA expression profiles of THY1 +-enriched undifferentiated spermatogonia were characterized, and members of Mir-17-92 (Mirc1) and its paralog Mir-106b-25 (Mirc3) clusters are significantly downregulated during retinoic acid-induced spermatogonial differentiation, both in vitro and in vivo. 13 Nov 2019 A computationally predicted shared target of the miR-17-92 miRNAs is the pro- apoptotic BCL-2 family protein BIM, central to life-death decisions Our recent discovery of a dual role of the miR-17-92 cluster, which shifts from oncogene to tumor suppressor during lymphoma progression, exemplifies the Recent studies have revealed the importance of multiple microRNAs (miRNAs) in promoting tumorigenesis, among which mir-17-92/Oncomir-1 exhibits potent 1 Apr 2020 For example, the primary microRNA-17-92 (pri-miR-17-92) cluster contains six microRNAs (miRNAs) that collectively act in several disease MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer 28 Mar 2019 The methylation of the miR-17-92 promoter was significantly increased (50%) upon EV71 infection, which appeared to be caused by the 20 Dec 2016 (2010) The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell 40(5):762–773. . The miR-17–92 cluster impairs TGF-β signaling response, and increases cell proliferation and promotes cell viability by activating the BRAF oncogene in thyroid Stem-loop sequence hsa-mir-17.
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It has two other paralogs in the human The miR-17-92 Cluster has been implicated in Medulloblastoma (MB) which is the most common paediatric malignant brain tumour. It arises when cerebellar 1 Jul 2020 MiRNAs have been the focus of many studies in the recent decade as miRNA profiles often change with disease onset.

1794. Med den senare upplöser Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som MicroRNA-17-92-klustret främjar proliferationen och kemokinproduktionen av keratinocyter: implikation för patogenesen av psoriasis.
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Microrna-17-92 reglerar myoblast-spridning och differentiering

Previous studies have shown that miR-17~92 promotes tumorigenesis and cancer angiogenesis in some tumor models. However, its role in the initiation and progression of CRC remains unknown. miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated miR-17 ~ 92 family as a master regulator of neurogenesis. Through targeting numerous genes that affect cell cycle arrest, stemness deprivation, and miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Patel V (1), Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P. The miR-17–92 cluster gene is primarily transcripted into an 800 bp long polycistron and is subsequently processed into 6 individual miRNAs (miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a). 12 The miR-17–92 cluster is broadly expressed at every stage of development, with the mature miRNAs detectable in almost all tissues at Survival analysis confirmed a high combined miRNA score of miR-17-92 cluster was associated with shorter biochemical recurrence interval.